Next generation Drosophila protein interactome map and its
Nodes Network nodes represent proteins
l 3 neo38 Lethal 3 neo38 isoform L Transcription regulatory region sequence specific DNA binding DNA binding transcription factor activity RNA polymerase II specific It is involved in the biological process described with regulation of chromatin silencing positive regulation of transcription by RNA polymerase II 455 aa
Finally to test whether regulation of melanic coloration by mir 193 is ancestral to Lepidoptera we tested its role in Drosophila melanogaster an outgroup species In these flies mir 193 is in a different genomic region lacks ivory and is located between two protein coding genes with the same transcription orientation Fig 4A
l 3 neo38 protein Drosophila melanogaster STRING
FlyBase Gene Report Dmel CG13950
A microRNA is the effector gene of a classic evolutionary
We apply state of the art methods to identify binary protein protein interactions PPIs for Drosophila melanogaster Four all by all yeast two hybrid Y2H screens of 10 000 Drosophila
L 3 Neo38 Protein Drosophila Melanogaster String
A Clk856 Gal4 drives GFP expression in most of the circadian clock neurons and some non clock neurons asterisk Only a few DN 3 are included in this Gal4 line Scale bar 50μm B Drosophila
Species specific expansion of C2H2 zinc finger genes and
Approximately 32 families exclusively belong to the silkworm and Drosophila such as the families of L 3 neo38 Tiptop BR C Fru Hkb Ab Ken Sens etc Table S2 These families might be selected to accommodate insect specific functions of biological processes during evolution
Mono methylation of Lysine 20 of histone H4 H4K20me1 is catalyzed by Set8 and thought to play important roles in many aspects of genome function that are mediated by H4K20me binding proteins
Drosophila melanogaster Set8 and L 3 mbt function in gene
For one such predicted neural regulator l 3 neo38 we generate a loss of function mutant and uncover an essential role for neuromuscular junction and brain development
Drosophila melanogaster Set8 and L 3 mbt function in gene
A Protein Interaction Map of Drosophila melanogaster
Lineage Resolved Enhancer and Promoter Usage during a Time
Specificity of modifiers for heterochromatic rearrangements
FlyBase Polypeptide Report Dmel l 3 neo38 PB
Here we present a two hybrid based protein interaction map of the fly proteome A total of 10 623 predicted transcripts were isolated and screened against standard and normalized complementary DNA libraries to produce a draft map of 7048 proteins and 20 405 interactions
Input control for ChIP seq on transgenic flies expressing l 3 neo38 eGFP fusion proteins
Here we describe the generation of a large scale Drosophila Protein interaction Map DPiM by coAP MS analysis based on 3 500 affinity purifications We developed a semi quantitative statistical approach to score protein interactions and defined a high quality map
ENCSR300JHR ENCODE
Enhancer promoter interactions become more instructive in the
Next generation large scale binary protein interaction
FlyAtlas2 A Drosophila melanogaster expression atlas with RNA Seq l 3 neo38 two hybrid GenBank Protein A collection of sequences
We describe a next generation Drosophila protein interaction map DPIM2 established from affinity purification mass spectrometry of 5 805 baits covering the largest fraction of the Drosophila proteome The network contains 32 668 interactions among 3 644 proteins organized into 632 clusters representing putative functional modules
A Protein Complex Network of Drosophila melanogaster PMC
l 3 neo43 protein Drosophila melanogaster STRING
l 3 neo38 Status UniProtKB unreviewed TrEMBL Drosophila melanogaster Fruit fly Amino acids 373 go to sequence Protein existence Evidence at protein
Mono methylation of Lysine 20 of histone H4 H4K20me1 is catalyzed by Set8 and thought to play important roles in many aspects of genome function that are mediated by H4K20me binding proteins
For one such predicted neural regulator we generate a l 3 neo38 loss of function mutant and uncover an essential role for neuromuscular junction and brain development
miR 137 regulates PTP61F affecting insulin signaling PNAS
FlyBase Gene Report Dmel l 3 neo38
In this study we reveal a role for miR 137 in metabolic homeostasis in Drosophila Drosophila has proven to be a valuable model for studying obesity energy metabolism and diabetes because organs signaling pathways and proteins involved are analogous to those in humans and most disease associated genes are conserved between Drosophila and humans reviewed in refs
Synaptic connectome of the Drosophila circadian clock
lethal 3 neo38 encodes an essential regulator of neuromuscular junction and brain development required at post embryonic stages
Lineage Resolved Enhancer and Promoter Usage Cell Press
For one such predicted neural regulator l 3 neo38 we generate a loss of function mutant and uncover an essential role for neuromuscular junction and brain development
Interestingly l 3 neo38 occupies a set of putative neuronal enhancers in the developing embryo and is required for the proper formation of the larval brain Reddington et al 2020 l
L 3 Neo38 Protein Drosophila Melanogaster String
The zinc finger protein CLAMP promotes long range chromatin interactions that mediate dosage compensation of the Drosophila male X chromosome Epigenetics Chromatin 14 29 2021
Lineage Resolved Enhancer and Promoter Usage during a Time
Drosophila melanogaster Set8 and L 3 mbt function in gene
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A0A0B4K6F4 UniProt
We interrogated this model in a developing animal by comparing in parallel the transcriptomes of Set8 null H4 K20R A and l 3 mbt mutant Drosophila melanogaster We found that the gene expression profiles of H4 K20A and H4 K20R larvae are markedly different than Set8 null larvae despite similar reductions in H4K20me1